Evolution might not be as neutral as researchers previously believed.

"Emerging research reveals that organisms may never fully catch up to their changing environments, opening new questions about how evolution really unfolds. Credit: Stock" (ScitechDaily, Evolution Is Not Neutral: New Study Challenges 60-Year Biology Theory)

Evolution bases the idea. That genetic mutation causes favorable or unfavorable changes in the species. When there are large beasts. In an area. The evolution starts to favor small-sized herbivorous animals. The outside effects are those beasts. They remove the large herbivores. From the population. That causes the enrichment. Of the genomes. Of small-sized herbivores. This means that. Some outside effects can cause. The enrichment of a certain type of genomes. And that can cause. That's some features. Of animals. Start to stand out. 

The outside effect can be the weather. Environment, epidemic, etc. But when evolution starts to enrich. Some types of genetic material. That causes mutations. Those mutations can be seen as a different living environment, a different shape, or a different behavior. This means that the members of the larger group can start discriminating against those mutated creatures. The genetic mutation can start. To create mutations. That makes the individuals look weird. In the eyes of the general population. 

This means the general population might not defend those minorities and think that they are “outsiders”. The genomes of the mutated bacteria. Might not fit. With genomes of the general groups. The large heritability might discriminate. Against their smaller companions. And that makes it hard to make descendants. Or the organism. That is adapted to a special ecosystem. Like living in caves without sunlight. Comes out of its cave. UV radiation can destroy that organism. Immediately. So, adaptation to an extreme environment can turn an organism unable to live outside that ecosystem. 

The ecosystem. That is a paradise for some species. It can be lethal for some other species.  The most common example. Among those things is a fish. Fish can live in water because they have gills. But if a fish comes out of the water, it dies quite soon. Here, I don’t handle things like lug fish. But if a human goes to the water. And tries to breathe there. Without scuba-diving equipment. Attempting to breathe underwater causes drowning. This is the description of natural evolution. 

But in the human-controlled evolution. The goal controls how researchers manipulate organisms and molecules. Sometimes those organisms are created that way. So that they have no ability to make descendants. Or they use some special nutrients that are not in natural environments. This is one thing that we must realize in the controlled evolution. The human-controlled evolution is never neutral. There are many things, like laws. That controls the evolution in laboratories. 

https://scitechdaily.com/evolution-is-not-neutral-new-study-challenges-60-year-biology-theory/

https://en.wikipedia.org/wiki/Neutral_theory_of_molecular_evolution