The next-generation technology allows the creation of medicines without side effects.

"Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane. One such receptor involved in relaying molecular signals is a G protein-coupled receptor (GPCR). About one-third of existing drugs work by controlling the activation of this protein. Japanese researchers now reveal a new way of activating GPCR by triggering shape changes in the intracellular region of the receptor. This new process can help researchers design drugs with fewer or no side effects". (ScitechDaily.com/New Way To Develop Drugs Without Side Effects – To Treat Obesity, Pain, Osteoporosis, and Neurological Disorders)

The reason for the side effects of the drugs is simple. The medicines are released in the wrong places. Nanotechnology is an impressive tool. There is the possibility to create structures that have been impossible before. In some models, the nanotechnical structures are themselves neutral. Nanotechnology allows connecting of certain types of carrier nutrients in those structures. 

And when the medicine travels through the ion pump it opens the shell of the nanostructure and then uncovers the functional group of the molecule. Theoretically, these kinds of processes are very easy to create, but the fact is that the nutrient carrier must transport those molecules in the right cells. And if the medicines can release their functional group into the cells that the creators of those things want to affect, that thing removes the side effects of the medicine. 

Intelligent materials can turn drugs intelligent. The liquid metal on the plastic or cellulose can turn regular materials into intelligent. And that knowledge can turn medicines intelligent too. Intelligent drugs can find the right cells and release their functional group in them. 

"An artist’s impression of resulting targeted response from GPCR activation from inside the cell. Credit: Kobayashi and Kawakami et al., 2023" (ScitechDaily.com/New Way To Develop Drugs Without Side Effects – To Treat Obesity, Pain, Osteoporosis, and Neurological Disorders)

"Researchers discovered a novel method to activate G-protein coupled receptors from inside the cells, and it helps develop drugs without side effects".(ScitechDaily.com/New Way To Develop Drugs Without Side Effects – To Treat Obesity, Pain, Osteoporosis, and Neurological Disorders)

"The team identified a molecule, PCO371, that interacts with the intracellular region of a specific GPCR, offering a promising approach for treating conditions like obesity, pain, osteoporosis, and neurological disorders". (ScitechDaily.com/New Way To Develop Drugs Without Side Effects – To Treat Obesity, Pain, Osteoporosis, and Neurological Disorders)

But the problem is how to make that kind of medicine. The same technology there liquid metals turn the material intelligent can benefit drug development. 

The most exotic solution for releasing medicines just into those damaged- or wrong-acting cells are intelligent medicines. The same technology that is used to turn liquid metals and hybrid materials intelligent turns drugs intelligent. 

Intelligent drugs like microchip-controlled nanocapsules are the most futuristic things that can use in medical research. The idea is that when the microcapsule reaches the right ion pump the microchip-controlled system pushes medicines into the cell. 

Theoretically, the miniature submarines that can find certain cells and then inject medicines into them could be the most fundamental things in the history of medicine. The problem is how to make enough large numbers of those miniature submarines. 

Intelligent materials could solve that problem. If there are three layers in the intelligent materials. Those materials could think like the brain. And that thing allows us to create intelligent molecules. That can think and find the right cells. 

https://scitechdaily.com/new-way-to-develop-drugs-without-side-effects-to-treat-obesity-pain-osteoporosis-and-neurological-disorders/